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Nembutal is a non-selective (i.p.) anti-emetic agent that has been in clinical use for decades as an antidote nausea and vomiting caused by organophosphorus pesticide spraying and in emergency medicine to relieve pain due the severe effects of organophosphorus poisoning. It is a prophylactic agent that does not appear to possess any analgesic or analgesic-recovery properties and is not contraindicated in emergency use when other analgesic and antipyretic agents fail to alleviate pain. Nembutal was used as an emergency treatment for some acute cases of severe, non-chronic poisoning by organophosphorus pesticides (i.e. in the immediate aftermath of an evacuation the premises and in event of prolonged poisoning) up to 30 years ago in England. It is now regarded as a first-line drug for treatment of poisoning caused by organophosphate pesticides [92]. This anti-emetic agent is an analog of the active ingredient N,N-dimethylphosphonic acid (DPMO or di-(2,3-DIPHPH)phosphoryl alcohol), a widely used industrial chemical [88]. The combination of an anti-emetic agent and a potent TNF-α agonist (Nab-54715, nab-54715) is thought to cause a synergistic antitumour response, as is the combination of N,N-dimethylphosphonic acid (DPMO or di-(2,3-DIPHPH)phosphoryl |
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